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Gel permeation chromatography: Differential operation
Author(s) -
Chuang JauYi,
Johnson Julian F.
Publication year - 1973
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1973.070170713
Subject(s) - gel permeation chromatography , permeation , chromatography , solvent , differential (mechanical device) , polymer , molar mass distribution , chemistry , materials science , membrane , thermodynamics , organic chemistry , biochemistry , physics
Operation of gel permeation chromatographs in the differential mode provides a sensitive method for detecting small differences in molecular weight distribution between similar samples. The solvent used in this case is a dilute solution of the reference polymer in an organic solvent. This solution is used in both the reference and the separation column. Samples of the material to be compared are injected in the normal manner. Only differences between the samples are reflected in the resulting chromatogram. For process control, this offers a simplified data presentation and should lead to easier detection of changes in operating conditions.