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The gel permeation chromatography of phenolic compounds
Author(s) -
Yoshikawa T.,
Kimura K.,
Fujimura S.
Publication year - 1971
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.1971.070151016
Subject(s) - chemistry , tetrahydrofuran , gel permeation chromatography , phenol , organic chemistry , solvent , size exclusion chromatography , formaldehyde , solvation , steric effects , hydrogen bond , polystyrene , polymer chemistry , molecule , polymer , enzyme
Gel permeation chromatography, using polystyrene gel and tetrahydrofuran as solvent, has been applied to hydroxybenzophenones, esters of salicylic acid, alkylphenols, alkylated methylenediphenols, and phenol–formaldehyde condensation products. The difference between the calculated molecular volume of these phenolic compounds and that obtained by actual determination with GPC has been ascribed to tetrahydrofuran solvation of the phenolic hydroxyl group. Furthermore, it has become clear that THF solvation is affected by the steric hindrance of ortho‐substituted phenol and by inactivation of the phenolic hydroxyl group resulting from internal hydrogen bonding.