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Effect of a polymerizable cosurfactant on the microstructure and drug‐release properties of nanoparticles synthesized through emulsion polymerization
Author(s) -
Bhawal Sumit,
Reddy L. Harivardhan,
Murthy R. S. R.,
Devi Surekha
Publication year - 2004
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.13666
Subject(s) - copolymer , monomer , methacrylate , polymer chemistry , emulsion , microstructure , methyl methacrylate , materials science , emulsion polymerization , chemical engineering , drug carrier , dispersion (optics) , polymerization , nanoparticle , (hydroxyethyl)methacrylate , drug delivery , polymer , composite material , nanotechnology , physics , optics , engineering
The emulsion copolymerization of a partially water‐soluble monomer, methyl methacrylate (MMA), and a water‐soluble polymerizable cosurfactant, hydroxyethyl methacrylate (HEMA), was investigated. The microstructure of the copolymer varied as the HEMA concentration increased. The copolymer microstructure influenced drug entrapment and was studied with respect to the variation in the MMA/HEMA ratio, the crosslinker concentration, and the method of nanoparticle separation from the dispersion. The subsequent release of a lipophilic drug, carbamazepine, from nanoparticles was studied at three different copolymer compositions. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 402–409, 2004