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Study of progesterone release mechanisms from a silicone matrix by a new analytical method
Author(s) -
Taghizadeh S. Mojtaba,
Mashak Arezou,
Jamshidi Ahmad,
Imani Mohammad
Publication year - 2004
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.13544
Subject(s) - silicone , matrix (chemical analysis) , solubility , materials science , diffusion , controlled release , silicone oil , polymer , chromatography , chemistry , chemical engineering , composite material , polymer chemistry , analytical chemistry (journal) , organic chemistry , thermodynamics , nanotechnology , physics , engineering
The release behavior of progesterone from a silicone matrix to release media containing 60% (v/v) alcohol and water was investigated and kinetically evaluated. For this purpose, samples containing 5, 10, or 15% (w/w) micronized progesterone were prepared through the mixing of two‐component silicone and the drug in a thermomixer. The discs were cured with compression molding. Then, the release from a controlled surface area was experimentally determined by a high‐performance thin‐layer chromatography technique, a new method for progesterone analysis. With Higuchi's model, the drug‐release behavior of the dispersion systems was determined by a partition‐controlled process (the relationship between the accumulated amount of the drug released and the time) and a matrix‐controlled process (the relationship between the accumulated amount of the drug released and the square root of time). The release profile determined by experimental data was in good agreement with Higuchi's model. Moreover, the product of the solubility and diffusivity of progesterone in the polymer matrix was evaluated and found to be 8.1 × 10 −7 mg/cm/s. Finally, the effects of fillers on the release behavior were studied. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 91: 3040–3044, 2004