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Cephazoline sodium release from poly( N ‐isopropyl acrylamide‐ co ‐ N , N ‐dimethylacrylamide) hydrogels
Author(s) -
Escobar J. L.,
García D.,
Valerino A.,
Zaldívar D.,
Hernáez E.,
Katime Issa
Publication year - 2004
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.13456
Subject(s) - self healing hydrogels , copolymer , swelling , polymer chemistry , acrylamide , poly(n isopropylacrylamide) , diffusion , kinetics , chemical engineering , polymer , chemistry , materials science , organic chemistry , thermodynamics , composite material , physics , quantum mechanics , engineering
Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water, preserving their shape. The dynamic swelling behavior of poly( N ‐isopropylacrylamide‐ co ‐ N,N ‐dimethylacrylamide) [poly(NIPA‐ co ‐DMA)] copolymers at 37°C was investigated. It was observed that the swelling degree in the copolymers decreases with the N ‐isopropylacrylamide content. In addition, the liberation mechanism was found to be Fickian. Diffusion coefficients according to Fick′s law as a function of the N ‐isopropylacrylamide concentration and results of the release process are reported. The kinetics of cephazoline sodium release from poly(NIPA‐ co ‐DMA) hydrogels with different compositions was studied. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 91: 3433–3437, 2004