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Swelling and drug‐release behavior of the poly(AA‐ co ‐ N ‐vinyl pyrrolidone)/chitosan interpenetrating polymer network hydrogels
Author(s) -
Lee WenFu,
Chiang WenHsuan
Publication year - 2003
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.13353
Subject(s) - self healing hydrogels , swelling , chitosan , interpenetrating polymer network , polymer chemistry , 2 pyrrolidone , polymer , materials science , acrylic acid , photopolymer , chemical engineering , composite material , copolymer , polymerization , engineering
A series of novel hydrogels were prepared from acrylic acid (AA), N ‐vinyl pyrrolidone (NVP), and chitosan by photopolymerization. The swelling behavior, gel strength, and drug release behavior of the poly(AA/NVP) copolymeric hydrogels and corresponding interpenetrating polymer network hydrogels were investigated. Results showed that the swelling ratios for the present hydrogels decreased with an increase of NVP content in the gel, but the gel strength increased with an increase of NVP content in the gel. Results also showed that the drug‐release behavior for the gels is related to the ionicity of drug and the swelling ratio of the gel. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 2135–2142, 2004