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Swelling and diffusion studies of poly( N ‐isopropylacrylamide/itaconic acid) copolymeric hydrogels in water and aqueous solutions of drugs
Author(s) -
Taşdelen Betül,
KayamanApohan Nilhan,
Güven Olgun,
Baysal Bahattin M.
Publication year - 2003
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.13223
Subject(s) - itaconic acid , self healing hydrogels , swelling , aqueous solution , methylene blue , polymer chemistry , nuclear chemistry , diffusion , chemistry , materials science , chemical engineering , copolymer , polymer , organic chemistry , composite material , catalysis , physics , photocatalysis , thermodynamics , engineering
N ‐Isopropylacrylamide/itaconic acid hydrogels (NIPAAm/IA) containing different amounts of itaconic acid prepared by irradiating with γ‐radiation were used in experiments on swelling and diffusion of the model drugs methylene blue, lidocaine, and sildenafil citrate (VIAGRA). The NIPAAm/IA hydrogels containing 0–3 mol % itaconic acid irradiated at 48 kGy has been used for swelling and diffusion studies in water and aqueous solutions containing the above‐mentioned model drugs. For these hydrogels, swelling studies indicated that swelling increased with the following order: water > lidocaine > methylene blue > VIAGRA. Diffusions of water and the drugs within hydrogels were found to be non‐Fickian in character. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 911–915, 2004