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Surface modification and in vitro blood compatibilities of polyurethanes containing z ‐lysine segments in the main chain
Author(s) -
Meng Wan,
Hyun JaeYong,
Song DongIk,
Kang InnKyu
Publication year - 2003
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.12904
Subject(s) - polymer chemistry , surface modification , contact angle , fourier transform infrared spectroscopy , chemistry , amine gas treating , attenuated total reflection , ethylene glycol , aqueous solution , nuclear chemistry , materials science , infrared spectroscopy , organic chemistry , chemical engineering , engineering , composite material
Polyurethanes containing z ‐lysine segments in the main chain (PULL) were synthesized from 4,4′‐diphenylmethyl diisocyanate, poly(tetramethylene glycol), and z ‐lysine oligomer as a chain extender. PULL film was treated with a 10% HBr–acetic acid solution and subsequently with a saturated sodium bicarbonate aqueous solution to produce a primary amine group on the surface. Heparin‐immobilized PULL (PULL‐H) was prepared by the coupling reaction of PULL surface amine groups and heparin carboxylic acid groups. The surface‐modified PULLs were then characterized by attenuated total reflection–Fourier transform infrared spectroscopy, electron spectroscopy for chemical analysis, and a contact angle goniometer. The concentration of amine groups and heparins introduced on the PULL surfaces were about 2.1 μmol/cm 2 and 1.9 μg/cm 2 , respectively. To assess in vitro blood compatibility, the interaction of modified PULLs with plasma proteins and platelets was examined. In the experiments with plasma proteins, plasma recalcification time and activated partial thromboplastin time were significantly prolonged on PULL‐H compared to those on the other surfaces. The percentage of serotonin released from platelets adhering on PULL‐H was less than that on the other surfaces, demonstrating a good in vitro blood compatibility. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 1959–1969, 2003