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A combinatorial approach in designing hydrophilic surfaces for solid‐phase peptide synthesis
Author(s) -
Ercole Francesca,
FitzGerald Michael,
Perera Senake,
Ede Nicholas,
Riley Phil,
Campbell Rhonda
Publication year - 2003
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.12574
Subject(s) - copolymer , solid surface , peptide , materials science , solid state , chemical engineering , polymer chemistry , phase (matter) , peptide synthesis , lantern , surface modification , chemistry , organic chemistry , polymer , composite material , engineering , biochemistry , chemical physics , ring (chemistry)
Abstract A hydrophilic surface suitable for solid‐state peptide synthesis was developed on a solid support called a lantern. The split‐and‐mix combinatorial technique was used to prepare about 500 surfaces in a very short time. Surfaces were analyzed according to values for gel formation, percentage weight grafted, grafted copolymer composition, and number of functional groups per lantern. These values were correlated to the purity of a peptide synthesized on these surfaces. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 3371–3378, 2003