Chemically treated hard gelatin capsules for colon‐targeted drug delivery: A novel approach | Zendy

Bajpai S. K. | Zendy; Bajpai M. | Zendy; Dengre R. | Zendy

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Chemically treated hard gelatin capsules for colon‐targeted drug delivery: A novel approach

Author(s) -

Bajpai S. K.,

Bajpai M.,

Dengre R.

Publication year - 2003

Publication title -

journal of applied polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.575

H-Index - 166

eISSN - 1097-4628

pISSN - 0021-8995

DOI - 10.1002/app.12478

Subject(s) - self healing hydrogels , gelatin , drug delivery , formaldehyde , aqueous solution , drug , polymer chemistry , chemistry , riboflavin , polyacrylamide , materials science , chemical engineering , organic chemistry , pharmacology , biochemistry , medicine , engineering

Hard gelatin capsules, containing riboflavin‐loaded poly ( N ‐viny1–2‐pyrrolidone)‐polyacrylamide cylindrical hydrogels, were modified chemically by treating with an aqueous formaldehyde solution for the purpose of delayed release of drug along the gastrointestinal tract. The t dis (disintegration time) of capsules was studied as a function of concentration of formaldehyde solution and the treatment time. The dynamic release of vitamin B 2 was studied as a function of crosslinking ratio of the hydrogels. The device studied seems to have potential to be used for colon‐targeted drug delivery. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 2277–2282, 2003

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