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Chemically treated hard gelatin capsules for colon‐targeted drug delivery: A novel approach
Author(s) -
Bajpai S. K.,
Bajpai M.,
Dengre R.
Publication year - 2003
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.12478
Subject(s) - self healing hydrogels , gelatin , drug delivery , formaldehyde , aqueous solution , drug , polymer chemistry , chemistry , riboflavin , polyacrylamide , materials science , chemical engineering , organic chemistry , pharmacology , biochemistry , medicine , engineering
Hard gelatin capsules, containing riboflavin‐loaded poly ( N ‐viny1–2‐pyrrolidone)‐polyacrylamide cylindrical hydrogels, were modified chemically by treating with an aqueous formaldehyde solution for the purpose of delayed release of drug along the gastrointestinal tract. The t dis (disintegration time) of capsules was studied as a function of concentration of formaldehyde solution and the treatment time. The dynamic release of vitamin B 2 was studied as a function of crosslinking ratio of the hydrogels. The device studied seems to have potential to be used for colon‐targeted drug delivery. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 2277–2282, 2003