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Interaction of a new anesthetic drug richlocain with linear and weakly crosslinked poly‐ N ‐vinylpyrrolidone
Author(s) -
Makysh G. Sh.,
Bimendina L. A.,
Murzagulova K. B.,
Kudaibergenov S. E.
Publication year - 2003
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.12410
Subject(s) - solvent , polymer chemistry , kinetics , polymer , anesthetic , drug , activation energy , chemistry , matrix (chemical analysis) , materials science , chemical engineering , organic chemistry , chromatography , physics , surgery , medicine , quantum mechanics , engineering , psychology , psychiatry
The properties of complexes of richlocain, a new local anesthetic drug, with linear and weakly crosslinked poly‐ N ‐vinylpyrrolidone were investigated with changes in media properties of pH, temperature, and solvent thermodynamic quality. The kinetics and activation energy of drug release from the gel matrix were determined. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 2977–2981, 2003