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Preparation and anticoagulant property of phosphorylcholine‐terminated o ‐benzoylchitosan derivative
Author(s) -
Zhu Aiping,
Zhang Jun,
Shen Jian
Publication year - 2003
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.11755
Subject(s) - phosphorylcholine , clotting time , blood clotting , acylation , chemistry , polymer chemistry , platelet , adhesion , solvent , materials science , organic chemistry , biochemistry , biomedical engineering , medicine , immunology , catalysis
To improve the solubility in organic solvent of chitosan, o ‐benzoylchitosan was synthesized by acylation with benzoyl chloride and then used in the reaction with 2‐chloro‐1,3,2‐dioxaphosphospholane (COP) to prepare phosphorylcholine‐terminated o ‐benzoylchitosan (PC‐BCS). PC‐BCS had a structure with a phospholipid polar group characterized by FTIR and 1 H NMR. PC‐BCS had been polysubstituted by a PC group, which made PC‐BCS viscous liquid. The anticoagulant properties of PC‐BCS were evaluated by means of blood‐clotting and platelet adhesion assay. The blood‐clotting assay indicated that PC‐BCS could prolong the blood‐clotting process. Platelet adhesion assay showed that PC‐BCS could effectively inhibit the platelet adhesion and activation. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 489–493, 2003