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Stability of DL ‐poly(lactic acid) in aqueous solutions
Author(s) -
Proikakis C. S.,
Mamouzelos N. J.,
Tarantili P. A.,
Andreopoulos A. G.
Publication year - 2002
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.11449
Subject(s) - lactic acid , hydrolysis , formaldehyde , swelling , condensation polymer , aqueous solution , polymer chemistry , polymer , chemistry , chemical engineering , nuclear chemistry , dynamic light scattering , materials science , organic chemistry , bacteria , composite material , nanotechnology , genetics , nanoparticle , engineering , biology
DL ‐poly(lactic acid) of molecular weight about 2500 was prepared by polycondensation of lactic acid and characterized by viscosimetry, infrared spectroscopy, light scattering, GPC, and NMR. Tablets made of the above polymer were immersed in buffer solutions at 37°C, and their swelling behavior was recorded as a function of time, in terms of weight gain. In the same experiments, the hydrolytic stability of PLA was assessed by measuring the weight loss after drying the tablets. To inhibit any degradation due to bacteria, formaldehyde was added to the solution as a biostatic factor. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 87: 795–804, 2003