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Segregation of resin‐bound peptides during solid‐phase synthesis
Author(s) -
Krishna Kumar I. M.,
Mathew Beena
Publication year - 2002
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.11079
Subject(s) - divinylbenzene , polystyrene , materials science , polymer chemistry , yield (engineering) , butanediol , sequence (biology) , copolymer , phase (matter) , monomer , peptide , chemical engineering , chemistry , composite material , polymer , organic chemistry , styrene , fermentation , engineering , biochemistry
To compare the segregation ability of 1,4‐butanediol dimethacrylate‐crosslinked polystyrene (BDDMA‐PS) and divinylbenzene‐crosslinked polystyrene (DVB‐PS), a set of difficult sequence peptides characterized by high‐arithmetic‐average β‐sheet stabilizing potential (SP β ) and low‐stepwise arithmetic average random coil conformational parameter ( P c *) were synthesized on both supports (∼ 2 mmol Cl g −1 ) under identical conditions. The yield and purity of the peptides obtained from BDDMS‐PS resin were higher than from DVB‐PS resin. The synthetic efficiency of the new support was found to be its ability to suppress the aggregation of growing peptide chains by β‐sheet formation. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1717–1723, 2002