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Synthesis and characterization of degradable copoly(ester–amide)s: Poly( trans ‐4‐hydroxy‐ L ‐proline‐ co ‐ε‐caprolactam)
Author(s) -
Lee RenShen,
Yang JenMing
Publication year - 2002
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.11048
Subject(s) - caprolactam , copolymer , glass transition , polymer chemistry , amide , molar ratio , chemistry , materials science , proton nmr , amorphous solid , catalysis , polymer , organic chemistry
Novel copolyesteramides were synthesized by reacting trans ‐4‐hydroxy‐ N ‐benzyloxycarbonyl‐ L ‐proline ( N ‐CBz‐Hpr) with ε‐caprolactam (CLM) in the presence of stannous octoate [Sn(II) Oct.] as a catalyst. Various techniques, including 1 H‐NMR, IR, DSC, and viscosity, were used to elucidate structural characteristics and thermal properties of the resulting copolymers. Data showed that the optimal reaction condition for the synthesis of the copolymers was obtained by using 3 wt % Sn(II) Oct. at 170°C for 24 h. The DSC analysis demonstrated amorphous structure for most of the copolymers. The glass‐transition temperature of the copolymers shifts to a higher temperature with increasing Hpr/CLM molar ratio. In vitro degradation of these poly( N ‐CBz‐Hpr‐ co ‐CLM)s was evaluated by weight loss measurements. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1615–1621, 2002