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Synthesis of terpolymers having a phospholipid polar group and poly(oxyethylene) in the side chain and their protein adsorption–resistance properties
Author(s) -
Oishi Tsutomu,
Tanaka Hiroaki,
Yamasaki Hirohito,
Onimura Kenjiro
Publication year - 2002
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.11037
Subject(s) - copolymer , polymer chemistry , methacrylate , adsorption , methyl methacrylate , polymer , membrane , side chain , materials science , chemistry , organic chemistry , biochemistry
Terpolymers having phospholipid polar groups were synthesized from 2 ‐ methacryloyloxyethyl phosphorylcholine (MPC), methacryloyl or acryloyl poly(oxyethylene) macromonomers (POEM) [(CH 2 CH 2 O) n (where n = 2–23); PEOM(2), PEOM(23), ME(9), Ph(6)], and n ‐butyl methacrylate (BMA). The characteristics of these terpolymer membranes were investigated by water content ( H ) and X‐ray photoelectron spectroscopy. The content of water in the terpolymer increased with increasing content of MPC and length of oxyethylene units. The membranes of terpolymers were found to adsorb bovine serum albumin much less than those of poly(methyl methacrylate) and poly(BMA). Even though the contents of MPC in the terpolymer were 5 to 25 mol %, the terpolymer depressed BSA adsorption more than poly(MPC‐ co ‐BMA) consisting of 29 mol % of MPC. The use of terpolymer with POEM can decrease the amount of MPC in the polymer. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1092–1105, 2002