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Investigation of loading and release in PVA‐based hydrogels
Author(s) -
Ruiz J.,
Mantecón A.,
Cádiz V.
Publication year - 2002
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.10696
Subject(s) - self healing hydrogels , cationic polymerization , vinyl alcohol , methylene blue , methyl orange , polymer chemistry , electrolyte , chemical engineering , chemistry , controlled release , materials science , organic chemistry , polymer , electrode , photocatalysis , engineering , catalysis
Abstract We used Methylene Blue (MB) and Methyl Orange (MO) as model drugs to investigate the controlled release behavior of hydrogels from poly(vinyl alcohol) crosslinked with ethylenediaminetetraacetic dianhydride. The cationic or anionic character of these compounds and the molecular weight between crosslinks of the hydrogel and the concentration of ionizable groups in the hydrogel greatly affected the loading and release of the drugs. MB loading was favored, therefore, by a higher content of negative charges in the hydrogel, although this implied a greater degree of crosslinking and, therefore, a lower mesh size. On the other hand, the overall loading of negative MO, favored by a higher mesh size, was very low because of unfavorable interactions with the electrolyte charges. Release studies showed that one of the parameters that most affected the drug release behavior of these hydrogels was the pH of the solution. MB and MO were not completely released, even at pH 1. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 85: 1644– 1651, 2002.