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Biodegradable block copolymers with poly(ethylene oxide) and poly(glycolic acid‐valine) blocks
Author(s) -
Feng Yakai,
Klee Doris,
Höcker Hartwig
Publication year - 2002
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.10461
Subject(s) - glycolic acid , copolymer , ethylene oxide , polymer chemistry , valine , crystallization , polymerization , materials science , monomer , oxide , chemistry , organic chemistry , polymer , amino acid , lactic acid , biochemistry , genetics , bacteria , biology
Biodegradable ABA triblock copolymers with poly(ethylene oxide) and poly(glycolic acid‐valine) blocks were synthesized via ring‐opening polymerization of cyclo(glycolic acid‐valine) using Ca‐alcoholates of hydroxytelechelic PEO as the initiator. The L‐valine residue racemized during copolymerization of cyclo(glycolic acid‐valine). The crystallization of the block copolymers decreases with decreasing PEO content in the triblock copolymers and with increasing length of the poly(glycolic acid‐valine) block. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2916–2919, 2002