Permeation of drugs in chitosan membranes | Zendy

Rocha A. N. L. | Zendy; Dantas T. N. C. | Zendy; Fonseca J. L. C. | Zendy; Pereira M. R. | Zendy

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Permeation of drugs in chitosan membranes

Author(s) -

Rocha A. N. L.,

Dantas T. N. C.,

Fonseca J. L. C.,

Pereira M. R.

Publication year - 2002

Publication title -

journal of applied polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.575

H-Index - 166

eISSN - 1097-4628

pISSN - 0021-8995

DOI - 10.1002/app.10185

Subject(s) - permeation , chitosan , membrane , isoniazid , drug , permeability (electromagnetism) , chemistry , chromatography , materials science , chemical engineering , polymer chemistry , nuclear chemistry , pharmacology , organic chemistry , medicine , tuberculosis , biochemistry , pathology , engineering

The permeabilities of isoniazid and amitriptyline hydrochloride in chitosan membranes were investigated. Drug concentration was changed from 0.1 to 1.0% while membrane thickness was varied from 40 to 150 μm. The release rate was measured in water at 30 ± 0.1°C by spectrophotometric determination. The drugs presented quite different permeabilities, which were related to their molecular weights; the permeabilities did not change with thickness or drug concentration for the ranges investigated. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 84: 44–49, 2002; DOI 10.1002/app.10185

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