Premium
Permeation of drugs in chitosan membranes
Author(s) -
Rocha A. N. L.,
Dantas T. N. C.,
Fonseca J. L. C.,
Pereira M. R.
Publication year - 2002
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.10185
Subject(s) - permeation , chitosan , membrane , isoniazid , drug , permeability (electromagnetism) , chemistry , chromatography , materials science , chemical engineering , polymer chemistry , nuclear chemistry , pharmacology , organic chemistry , medicine , tuberculosis , biochemistry , pathology , engineering
Abstract The permeabilities of isoniazid and amitriptyline hydrochloride in chitosan membranes were investigated. Drug concentration was changed from 0.1 to 1.0% while membrane thickness was varied from 40 to 150 μm. The release rate was measured in water at 30 ± 0.1°C by spectrophotometric determination. The drugs presented quite different permeabilities, which were related to their molecular weights; the permeabilities did not change with thickness or drug concentration for the ranges investigated. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 84: 44–49, 2002; DOI 10.1002/app.10185