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Use of linear solvation energy relationships for chromatographic retention of seven solutes in different mobile phases
Author(s) -
Han Dandan,
Tian Minglei,
Row Kyung Ho
Publication year - 2011
Publication title -
asia‐pacific journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.348
H-Index - 35
eISSN - 1932-2143
pISSN - 1932-2135
DOI - 10.1002/apj.596
Subject(s) - chemistry , solvation , bromide , acetonitrile , phosphate , intermolecular force , chromatography , sodium , phase (matter) , sodium dodecyl sulfate , inorganic chemistry , ion , organic chemistry , molecule
The linear solvation energy relationship (LSER) model was utilized to delineate which specific intermolecular interactions are responsible for changes in retention for a variety of well‐characterized analytes when different additives were used in reversed‐phase high‐performance liquid chromatography. The effects of additives such as organic [sodium dodecyl sulfate (SDS), cetyltrimethylammonium bromide (CTAB)] and inorganic [sodium dihydrogen phosphate (NaH 2 PO 4 ), disodium hydrogen phosphate (Na 2 HPO 4 )] salts with 30–50% (v/v) acetonitrile (ACN) on the LSER coefficients were studied. The ability of the LSER model to account for the chemical interactions underlying solute retention was demonstrated. LSER as a potential predictive tool can direct us to choose proper mobile phase additive to separate different kinds of compounds. Copyright © 2011 Curtin University of Technology and John Wiley & Sons, Ltd.