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Synthesis of 3‐methyl‐N‐substituted‐1H‐indole
Author(s) -
Zhang XiaoLin,
Zhang WeiHua,
Yang HongXia Ou
Publication year - 2009
Publication title -
asia‐pacific journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.348
H-Index - 35
eISSN - 1932-2143
pISSN - 1932-2135
DOI - 10.1002/apj.348
Subject(s) - indole test , chemistry , intramolecular force , stereochemistry
A practical synthesis of 3‐methyl‐N‐substituted‐1H‐indole (N‐substituted‐skatole) starting from 2‐halogen phenylamine was described, by following acetylation or sulfonylation, alkylation and the intramolecular Heck reaction. In this article, effects of the reactions temperature, solvent, time, proportion and the mount of catalyst were investigated. Target product has an application prospect. Copyright © 2009 Curtin University of Technology and John Wiley & Sons, Ltd.