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Development of electrochemical noninvasive glucose nanobiosensor using antioxidants as a novel mediator
Author(s) -
Poursadeghian Sepideh,
Rabiee Mohammad,
Moshayedi Hamid Reza,
Karimi Meysam,
Tahriri Mohammadreza,
Tayebi Lobat
Publication year - 2017
Publication title -
asia‐pacific journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.348
H-Index - 35
eISSN - 1932-2143
pISSN - 1932-2135
DOI - 10.1002/apj.2143
Subject(s) - biosensor , cyclic voltammetry , fourier transform infrared spectroscopy , mediator , scanning electron microscope , chemistry , materials science , electrochemistry , polyvinyl alcohol , electrode , analytical chemistry (journal) , biomedical engineering , chromatography , nanotechnology , chemical engineering , medicine , organic chemistry , composite material , engineering
Diabetes mellitus is a chronic disease, and millions of people die from its related disorders each year; thus, people with diabetes have to control the level of blood glucose frequently. In the last decade, the noninvasive biosensors have been considered to track glucose level without finger pricking. In this research, the glucose biosensor was developed using a new formulation containing hydroxylmethoxyphenyl derivation as a novel mediator that was extracted from a natural source. The mediator characterization was performed by means of thin‐layer chromatography and Fourier transform infrared spectroscopy, and the electrochemical activity of the prepared biosensor was evaluated by Autolab potentiostate machine. Scanning electron microscope micrographs revealed a flat surface on the modified electrode that is crucial in electron conduction equivalence. The cyclic voltammetry examination ascertained the irreversible oxidative reaction of phenolic mediator that leads the biosensor system to more electron formation. The obtained results demonstrated that antioxidants could improve the electron forming and also it could enhance the current signal. Finally, response time could be controlled by variation in polyvinyl alcohol concentration.