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Study on kinetics of reactive extraction of propranolol enantiomers by multiple linear regression method
Author(s) -
Zhang Panliang,
Cheng Qing,
Tang Kewen,
Qiu Yunren,
Xu Weifeng,
Jiang Pan,
Dai Guilin
Publication year - 2017
Publication title -
asia‐pacific journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.348
H-Index - 35
eISSN - 1932-2143
pISSN - 1932-2135
DOI - 10.1002/apj.2097
Subject(s) - chemistry , enantiomer , boric acid , propranolol , reaction rate constant , linear regression , extraction (chemistry) , kinetics , aqueous solution , reaction rate , chromatography , stereochemistry , organic chemistry , mathematics , catalysis , physics , statistics , medicine , quantum mechanics
Kinetic study on reactive extraction of propranolol (Pra) enantiomers with di‐cyclohexyl (D)‐tartrate (DT) and boric acid (BA) as combined chiral selector was performed in a modified Lewis cell. The effects of agitation speed, interfacial area, pH value of aqueous phase, as well as initial concentrations of DT, BA and Pra enantiomers on extraction rate were investigated. The experimental data were analyzed by multiple linear regression method to evaluate some important parameters. It was found that the interfacial reaction is 0.4, 0.8 and 0.8 order separately with respect to BA, Pra and DT, and the forward rate constants have been found to be 5.08 × 10 −4 L/(mol s) for (R)‐Pra and 2.42 × 10 −4 L/(mol s) for (S)‐Pra. An interfacial reaction mechanism was proposed to understand the rate equation. © 2017 Curtin University of Technology and John Wiley & Sons, Ltd.