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Regenerative Wound Surgery: Practical Application of Regenerative Medicine in the OR
Author(s) -
Gillette Brian,
Criscitelli Theresa,
Howell Raelina,
Woods Jon,
Acerra Michael,
Gorenstein Scott
Publication year - 2019
Publication title -
aorn journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 43
eISSN - 1878-0369
pISSN - 0001-2092
DOI - 10.1002/aorn.12615
Subject(s) - regenerative medicine , wound healing , decellularization , medicine , debridement (dental) , surgery , modalities , wound care , regeneration (biology) , therapeutic modalities , tissue engineering , stem cell , intensive care medicine , biomedical engineering , biology , social science , genetics , sociology , microbiology and biotechnology , physical therapy
Abstract Chronic nonhealing wounds cause significant morbidity and mortality and remain a challenging condition to treat. Regenerative wound surgery involves operative debridement of wounds to remove dead and healing‐impaired tissue and bacterial contamination and, subsequently, the application of regenerative medicine treatments to accelerate healing. Regenerative treatments aim to restore native tissue structure and function by targeting biological mechanisms underlying impaired healing. A wide range of regenerative modalities are used for treating chronic and complex wounds, including decellularized scaffolds, living engineered donor tissues, autologous stem cells, and recombinant growth factors. Each of these modalities has specific and sometimes complex requirements for implementation. The advanced wound care team, including OR staff members, should be aware of how these products are used and regulated. This article highlights some of the common and emerging regenerative treatments that are applied in wound surgery and focuses on how the products are used practically in the OR .