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Formulation and Characterization of Novel Nanostructured Lipid Carriers with Photoprotective Properties Made from Carnauba Wax, Beeswax, Pumpkin Seed Oil, and UV Filters
Author(s) -
Chu Chee Chin,
Hasan Zafarizal Aldrin Bin Azizul,
Chua Siaw Kim,
Nyam Kar Lin
Publication year - 2020
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1002/aocs.12340
Subject(s) - carnauba wax , beeswax , wax , dispersity , materials science , particle size , chromatography , zeta potential , chemistry , chemical engineering , nanoparticle , nanotechnology , composite material , polymer chemistry , engineering
Pumpkin seed oil (PSO) with carnauba wax and beeswax was used to develop nanostructured lipid carriers (NLC) loaded with a UV filter, Uvinul® A Plus B. The aims of the study were to optimize the concentration of PSO to develop a stable NLC formulation, determine storage stability of the NLC with and without PSO, and the synergistic effect of PSO‐NLC with UV filter for photoprotective properties. The physical properties of NLC were optimized based on the mean particle size, polydispersity index, and storage stability. The optimized NLC consisted 10% lipid phase (3.5% carnauba wax, 3.5% beeswax, and 3.0% PSO) and 90% aqueous phase. After optimization, Uvinul® A Plus B was added in the optimized PSO‐NLC to produce a photoprotective formulation. Uvinul® A Plus B consisted of both UVA (Diethylamino Hydroxybenzoyl Hexyl Benzoate) and UVB (Ethylhexyl Methoxycinnamate) filters. The NLC produced with PSO and Uvinul® A Plus B had mean particle size of 135 ± 2 nm and showed good physical stability under storage time. Besides that, the NLC produced also proven to have positive effect in enhancing the entrapment efficiency and drug loading, which were 82.86 ± 0.15% and 55.41 ± 0.04%, respectively, and showed sun protection factor value of 16.61 ± 3.45. The results indicated the presence of synergistic effect among the PSO‐NLC with Uvinul® A Plus B.