Synthesis, characterization and biological activity of a novel binuclear organotin complex, Ph 3 Sn(HL)·Ph 2 SnL [L = 3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH(i‐Pr)COO] | Zendy

Tian Laijin | Zendy; Sun Yuxi | Zendy; Qian Bochu | Zendy; Yang Guoming | Zendy; Yu You | Zendy; Shang Zhicai | Zendy; Zheng Xiaoliang | Zendy

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Synthesis, characterization and biological activity of a novel binuclear organotin complex, Ph 3 Sn(HL)·Ph 2 SnL [L = 3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH(i‐Pr)COO]

Author(s) -

Tian Laijin,

Sun Yuxi,

Qian Bochu,

Yang Guoming,

Yu You,

Shang Zhicai,

Zheng Xiaoliang

Publication year - 2005

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.968

Subject(s) - chemistry , carboxylate , trigonal bipyramidal molecular geometry , methylene , stereochemistry , tin , antibacterial activity , medicinal chemistry , chloride , benzene , molecule , organic chemistry , bacteria , biology , genetics

A 1:1 reaction of triphenyltin chloride with potassium N ‐[(3,5‐dibromo‐2‐hydroxyphenyl)methylene] valinate in benzene under reflux leads to the formation of a novel mixed organotin binuclear complex, Ph 3 Sn(HL)·Ph 2 SnL [L = 3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH(i‐Pr)COO], by means of a facile phenyl–tin bond cleavage process. The X‐ray structure reveals that there are two distinct types of carboxylate coordination mode and trans ‐O 2 SnC 2 N and trans ‐O 2 SnC 3 in distorted trigonal bipyramidal geometries. The complex displays good in vitro cytotoxicity and antibacterial activities. Copyright © 2005 John Wiley & Sons, Ltd.

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