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Synthesis, characterization and biological activity of a novel binuclear organotin complex, Ph 3 Sn(HL)·Ph 2 SnL [L = 3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH(i‐Pr)COO]
Author(s) -
Tian Laijin,
Sun Yuxi,
Qian Bochu,
Yang Guoming,
Yu You,
Shang Zhicai,
Zheng Xiaoliang
Publication year - 2005
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.968
Subject(s) - chemistry , carboxylate , trigonal bipyramidal molecular geometry , methylene , stereochemistry , tin , antibacterial activity , medicinal chemistry , chloride , benzene , molecule , organic chemistry , bacteria , biology , genetics
A 1:1 reaction of triphenyltin chloride with potassium N ‐[(3,5‐dibromo‐2‐hydroxyphenyl)methylene] valinate in benzene under reflux leads to the formation of a novel mixed organotin binuclear complex, Ph 3 Sn(HL)·Ph 2 SnL [L = 3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH(i‐Pr)COO], by means of a facile phenyl–tin bond cleavage process. The X‐ray structure reveals that there are two distinct types of carboxylate coordination mode and trans ‐O 2 SnC 2 N and trans ‐O 2 SnC 3 in distorted trigonal bipyramidal geometries. The complex displays good in vitro cytotoxicity and antibacterial activities. Copyright © 2005 John Wiley & Sons, Ltd.