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Synthesis and characterization of ferrocenylalkoxygermatranes and crystal structures of FcCH 2 OGe (OCH 2 CH 2 ) 3 N and FcCH(CH 3 )OGe(OCH 2 CH 2 ) 3 N 1
Author(s) -
Chen JianXin,
Sun Lijuan,
Xie Qinglan
Publication year - 2005
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.954
Subject(s) - chemistry , moiety , yield (engineering) , stereochemistry , metallurgy , materials science
Abstract Germatranes bearing a ferrocenylalkoxyl moiety have been obtained by the reaction of HOGe(OCH 2 CH 2 ) 3 N with various ferrocenyl alcohols. A convenient new synthesis method of FcCH 2 OGe(OCH 2 CH 2 ) 3 N was reported. FcCH 2 OGe(OCH 2 CH 2 ) 3 N was prepared in 93% yield when FcCH 2 OH reacted with HOGe(OCH 2 CH 2 ) 3 N in chloroform at room temperature in the presence of molecular sieves (3 Å) as a dehydrating agent. All compounds were characterized by elemental analysis, 1 H NMR and IR spectroscopy. The molecular structures of FcCH 2 OGe(OCH 2 CH 2 ) 3 N and FcCH(CH 3 )OGe(OCH 2 CH 2 ) 3 N have been determined by X‐ray diffraction. The antitumor activities of FcCH 2 OGe(OCH 2 CH 2 ) 3 N and p ‐FcC 6 H 4 CH 2 OGe(OCH 2 CH 2 ) 3 N were determined. Copyright © 2005 John Wiley & Sons, Ltd.