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Synthesis, characterization and biological properties of vanadyl(IV) complexes of diclofenac and indomethacin: an experimental and theoretical study
Author(s) -
Williams Patricia A. M.,
Molinuevo María S.,
Okulik Nora,
Jubert Alicia H.,
Etcheverry Susana B.
Publication year - 2005
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.879
Subject(s) - chemistry , diclofenac , vanadium , ab initio , fourier transform infrared spectroscopy , characterization (materials science) , nuclear chemistry , stereochemistry , computational chemistry , inorganic chemistry , organic chemistry , nanotechnology , chemical engineering , biochemistry , materials science , engineering
Two new vanadyl(IV) complexes with the non‐steroidal antiinflammatory drugs Indomethacin and Diclofenac were synthesized and characterized by elemental analysis, electronic, diffuse reflectance and FTIR spectroscopies and thermal behavior. The structures of the oxo‐vanadium(IV) complexes were obtained by carrying out ab initio calculations (B3LY/3–21G**) owing to the difficulties of obtaining single crystals of good quality for X‐ray studies. Indomethacin and Diclofenac did not cause any effect when tested on cellular proliferation in two osteoblast‐cell lines in culture (MC3T3E1 and UMR106). The biological effect of the complexes depends on the cellular type and on the nature of the coordinated ligands. Copyright © 2005 John Wiley & Sons, Ltd.