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Speciation of organotin compounds in NaCl aqueous solution: interaction of mono‐, di‐ and tri‐organotin(IV) cations with nucleotide 5′ monophosphates
Author(s) -
De Stefano Concetta,
Gianguzza Antonio,
Giuffrè Ottavia,
Piazzese Daniela,
Orecchio Santino,
Sammartano Silvio
Publication year - 2004
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.728
Subject(s) - chemistry , aqueous solution , hydrolysis , nucleotide , medicinal chemistry , genetic algorithm , stereochemistry , organic chemistry , biochemistry , evolutionary biology , biology , gene
Formation constants for complex species of mono‐, di‐ tri‐alkyltin(IV) cations with some nucleotide 5′‐monophosphates (AMP, UMP, IMP GMP) are reported, at T = 25 °C at I = 0.16 mol l −1 (NaCl). The investigation was performed in the light of speciation of organometallic compounds in natural fluids in the presence of nucleotides whose biological importance is well recognized. The simple mixed hydrolytic complex species formed in all the systems investigated in the pH range 3–9 are (L = nucleotide; M = organotin cation R x Sn (4− x )+ , with x = 1 to 3): ML + , ML(OH) 0 ML(OH) 2 − for the system CH 3 Sn 3+ –L (L = AMP, IMP, UMP); ML 0 ML(OH) − for the system (C 2 H 5 ) 2 Sn 2+ –L (L = AMP, IMP, UMP); ML − , ML(OH) 2− , MLH 0 M 2 L(OH) − for the system (C 2 H 5 ) 3 Sn + –L (L = AMP); ML, ML(OH) 2− M 2 L 0 for the system (C 2 H 5 ) 3 Sn + –L (L = IMP, UMP). As expected, owing to the strong tendency of organotin(IV) cations to hydrolysis in aqueous solution, the main species formed in the pH range of interest of natural fluids are the mixed hydrolytic ones. Copyright © 2004 John Wiley & Sons, Ltd.