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Synthesis, structural studies and some biological aspects, including nematicidal and insecticidal properties, of organotin(IV) complexes formed with biologically active sulfonamide imine ligand
Author(s) -
Jain Mukta,
Maanju Sunita,
Singh R. V.
Publication year - 2004
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.711
Subject(s) - chemistry , imine , sulfonamide , stereochemistry , ligand (biochemistry) , trigonal bipyramidal molecular geometry , tin , chelation , biological activity , antifungal , coordination sphere , medicinal chemistry , combinatorial chemistry , organic chemistry , crystal structure , biochemistry , medicine , receptor , dermatology , in vitro , catalysis
Abstract The synthetic, spectroscopic and biological studies of some organotin(IV) complexes derived from sulfonamide imine having a nitrogen–nitrogen donor system have been undertaken. The sulfonamide imine, on interaction with organotin(IV) chlorides, yields complexes having an Sn←N bond. The structures of these compounds have been elucidated by microestimations and spectral (UV, IR, 1 H, 13 C and 119 Sn NMR) studies, which unerringly point to the trigonal bipyramidal and octahedral geometries for the unimolar and bimolar reactions respectively around tin(IV), as the active lone pair of nitrogen is also included in the coordination sphere. Studies were conducted to assess the comparative growth‐inhibiting potential of the synthesized complexes against the sulfonamide imine for a variety of fungal and bacterial strains. The studies demonstrate that the concentrations reached levels sufficient to inhibit and kill the pathogens. The results of the biological studies have also been compared with the conventional standards, Bavistin and Streptomycin, taken for antifungal and antibacterial activities respectively. The complexes also show higher nematicidal and insecticidal properties. Copyright © 2004 John Wiley & Sons, Ltd.