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Evaluation of in vivo acute immunotoxicity of arsenocholine, a trimethyl arsenic compound in seafood
Author(s) -
Sakurai Teruaki,
Ochiai Masayuki,
Kojima Chikara,
Ohta Takami,
Fujiwara Kitao
Publication year - 2005
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.695
Subject(s) - in vivo , chemistry , immune system , acute toxicity , arsenic , pharmacology , toxicity , in vitro , median lethal dose , effector , biochemistry , immunology , biology , microbiology and biotechnology , organic chemistry
In this study, we observed the first in vivo acute immunotoxicity of a trimethyl(2‐hydroxyethyl)arsonium cation, namely arsenocholine (AsCho), which is present in marine animals that are ingested daily as seafood in many countries. It has been reported that AsCho has significant acute in vivo toxicity. A high dose of the synthetic pure AsCho was administered to CDF 1 mice intraperitoneally (0.1 g kg −1 mouse weight) or orally (a total of 10.0 g kg −1 mouse weight); its effect on the immune organs and immune effector cells was assessed. Administered AsCho, especially via the oral route, showed weak and partial, but significant, in vivo immunotoxicity in mice, although it did not cause any severe acute inflammatory responses. Copyright © 2005 John Wiley & Sons, Ltd.