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Synthetic and antimicrobial studies on new gold(I) complexes of imidazolidin‐2‐ylidenes
Author(s) -
Özdemir İsmail,
Denizci Akın,
Öztürk H. Tansel,
Çetinkaya Bekir
Publication year - 2004
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.668
Subject(s) - chemistry , enterococcus faecalis , minimum inhibitory concentration , antimicrobial , escherichia coli , derivative (finance) , staphylococcus aureus , staphylococcus epidermidis , stereochemistry , medicinal chemistry , ring (chemistry) , antibacterial activity , nuclear chemistry , bacteria , organic chemistry , biochemistry , genetics , biology , financial economics , economics , gene
Six new 1,3‐diorganylimidazolidin‐2‐ylidene (NHC) gold(I) complexes of the type [Au(NHC) 2 ] + (1–6), were synthesized by reacting [AuCl(PPh) 3 ] with 1,3‐dimesitylimidazolidin‐2‐ylidene or bis(1,3‐dialkylimidazolidin‐2‐ylidene). The complexes 1–6 were fully characterized by elemental analyses and spectroscopic data. The placement of mesityl or para‐substituted benzyl groups on the nitrogen atoms of the ring of the complexes leads to the particularly active antibacterial agents evaluated in this work. It is worth noting that the p ‐methoxybenzyl derivative (2) inhibited the growth of Pseudomona aeruginosa, Staphylococcus epidermidis, Staphylococcus aureus and Enterococcus faecalis with minimum inhibitory concentration (MIC) values of 3.12 µg ml −1 , 6.25 µg ml −1 , 3.12 µg ml −1 and 3.12 µg ml −1 respectively. In contrast, the analogous p ‐dimethylaminobenzyl derivative (3) is effective only against Escherichia coli (MIC = 3.12 µg ml −1 ). Copyright © 2004 John Wiley & Sons, Ltd.