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The role of cobalt, copper, nickel, and zinc in the DNA replication inhibitory activity of p ‐aminophenyl triphenylporphyrin
Author(s) -
Barragán Efraín,
Gordillo Barbara,
Vargas Genaro,
Velazco Luis
Publication year - 2004
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.649
Subject(s) - chemistry , dna , cationic polymerization , porphyrin , rna , cobalt , intercalation (chemistry) , zinc , dna replication , copper , inhibitory postsynaptic potential , stereochemistry , biochemistry , polymer chemistry , inorganic chemistry , organic chemistry , gene , neuroscience , biology
Cationic porphyrins have been widely used as tumor localizers in cancer therapies. When cationic porphyrins are flat they intercalate with double‐stranded DNA, duplexes of RNA or RNA–DNA. The antitumor activity of some cationic porphyrins depends on their interaction with human telomeric quadruplexes. Here, we report that noncationic meso ‐(4‐aminophenyl)triphenylporphyrin (H 2 TPPNH 2 ) ( 3 ) and its cobalt, copper, nickel, and zinc metallo derivatives ( 4 – 7 ) have DNA replication inhibitory activity in B16 mouse melanoma line cells. By means of quantification of 3 HdTT radio‐labeled DNA, we observed that the nonplanar porphyrin [CoTPPNH 2 ] has the highest activity against carcinogenic DNA replication. Copyright © 2004 John Wiley & Sons, Ltd.