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Germaselenazolidines and germadiselenoacetals: syntheses and radioprotective properties
Author(s) -
Célariès Benoît,
Amourette Christine,
Lion Claude,
Rima Ghassoub
Publication year - 2004
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.632
Subject(s) - chemistry , selenium , toxicity , stereochemistry , acute toxicity , pharmacology , combinatorial chemistry , organic chemistry , medicine
A series of organogermanium structures (cyclic or linear) containing selenium has been prepared to be studied in chemical radioprotection. We report the syntheses, characterization and properties of germaselenazolidines and germadiselenoacetals derived from selenocysteamine and methylselenocysteamine. The radioprotective activity was evaluated in mice by intraperitoneal (i.p.) injection. For the selenazolidines, the presence of a methyl group, in the α position of the selenium, decreases the radioprotective efficacy and increases the toxicity, whereas for the diselenoacetals it leads to a reduction of the radioprotective properties and a reduction of the toxicity. Copyright © 2004 John Wiley & Sons, Ltd.