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Silica immobilized copper N‐heterocyclic carbene: An effective route to 1,2,3‐triazoles via azide‐alkyne cycloaddition and multicomponent click reaction
Author(s) -
Garg Anirban,
Borah Nobomi,
Sultana Jasmin,
Kulshrestha Akshay,
Kumar Arvind,
Sarma Diganta
Publication year - 2021
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.6298
Subject(s) - cycloaddition , alkyne , chemistry , azide , catalysis , carbene , click chemistry , triazole , aryl , x ray photoelectron spectroscopy , combinatorial chemistry , copper , polymer chemistry , organic chemistry , alkyl , chemical engineering , engineering
A new silica supported copper N‐heterocyclic carbene (Cu‐NHC@SiO 2 ) complex is prepared and characterized by scanning electron microscopy (SEM), energy dispersive X‐ray spectroscopy (EDX) and X‐ray photoelectron spectroscopy (XPS) analyses. This complex is an efficient and easily retrievable catalyst for 1,2,3‐triazole synthesis through direct azide‐alkyne cycloaddition reaction as well as one‐pot reaction using arylboronic acids. This catalytic system is also suitable for synthesis of 4‐aryl‐NH‐1,2,3‐triazoles from diverse benzaldehydes. Further, the catalyst can efficiently be recycled up to fifth cycle for all the three methods of 1,2,3‐triazole synthesis through direct azide‐alkyne cycloaddition and multi‐component reactions.