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Rhodium catalyzed 2‐alkyl‐benzimidazoles synthesis from benzene‐1,2‐diamines and tertiary alkylamines as alkylating agents
Author(s) -
Sharma Saurabh,
Das Pralay
Publication year - 2021
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.6278
Subject(s) - chemistry , rhodium , catalysis , alkyl , benzene , organic chemistry , diamine , substrate (aquarium) , medicinal chemistry , oceanography , geology
Substituted 2‐alkyl‐benzimidazoles were synthesized from benzene‐1,2‐diamine and tertiary amines as alkylating agent under polystyrene supported rhodium (Rh@PS) nanoparticles (NPs) catalyzed conditions. The heterogeneous rhodium catalyst was applied first time for the synthesis of 2‐alkyl‐benzimidazoles. The reaction followed through oxidation of alkylamines, transamination, and oxidative cyclisation with benzene‐1,2‐diamines for the corresponding products synthesis with good yields. The process is applicable for vast substrate scope, several functional groups are tolerable, and the Rh@PS catalyst is recyclable up to four cycles without significant loss in catalytic activity.