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Novel nanoformulated combination of Se and CeO 2 particles loaded polylactic‐co‐glycolic acid vesicle to improved anti‐inflammation and auto‐regenerative for the treatment and care of spinal cord injury
Author(s) -
Wang Xiaoying,
Li Biao,
Fan Jingjing,
Tian Shanshan,
Wei Xiangyang
Publication year - 2021
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.6269
Subject(s) - plga , nanocarriers , polylactic acid , biocompatibility , nanomaterials , chemistry , fourier transform infrared spectroscopy , scanning electron microscope , glycolic acid , chemical engineering , nanotechnology , nanoparticle , x ray photoelectron spectroscopy , materials science , nuclear chemistry , polymer , organic chemistry , lactic acid , composite material , biology , bacteria , engineering , genetics
Polymer functionalized nanoparticles (NPs) have a great attention in biomedical applications owing to their unique properties like regenerative antioxidant, anti‐inflammatory, auto‐catalytic properties, and biocompatibility. In this current work, we demonstrated a facile synthesis of Se‐CeO 2 via chemical method followed by precipitation method. The prepared Se NPs were characterized by ultraviolet–visible (UV‐vis) spectroscopy, and the size and morphology of the NPs were analysed using transmission electron microscopy (TEM). Meanwhile, Se‐CeO 2 NPs loaded on polylactic‐co‐glycolic acid (PLGA) nanocarrier were characterised by Fourier transform infrared (FT‐IR), scanning electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS), TEM, and energy dispersive X‐ray analysis (EDAX) mapping techniques. The morphological and spectroscopic investigations of prepared nanomaterials have exhibited favourable morphological structure and chemical interactions with respective polymeric molecules, which established that nanovesicle suitability for the SCI functional recovery. We first investigated Se nanoformulated CeO 2 material for the potential healing of in vitro spinal cord study. Our results demonstrated that preparation of NPs loaded PLGA nanocarrier has provide effective spinal cord regeneration and imply that it was explored that promising nanocarrier in the SCI treatment. Se‐NPs encapsulated CeO 2 nanostructures administrations for SCI therapies have greatly suppressed oxidative stress and induced anti‐inflammatory action, which leads to prospective therapeutic benefits of spinal cord regeneration. These investigative results demonstrate that Se‐CeO 2 NPs with PLGA carrier could have great attention for effecient functional recovery treatment and care for spinal cord injury.