Supramolecular complexes of Ni (II) and Co (II) 4‐aminobenzoate with 3‐cyanopyridine: Synthesis, spectroscopic characterization, crystal structure, and enzyme inhibitory properties

Two new complexes, [M (AB) 2 (CP) 2 (H 2 O) 2 ] (where M = Ni and Co AB = 4‐aminobenzoate and CP = cyanopyridine), were synthesized and characterized using different techniques (elemental analysis, FT‐IR spectrophotometer, LC/MS, single‐crystal X‐ray diffraction, and TGA/DTA analysis). As a result of X‐ray structural analysis, it was determined that complexes are isostructural. In the crystalline structures, M II ions are bridged with their carboxylate oxygen and aminopyridine nitrogen atoms and their symmetry‐related counterparts to form a two‐dimensional polymeric structure. The M II ion is octa‐coordinated with two nitrogen atoms and two oxygen atoms of the AB and two atoms of the CP anions. In this study, the effect of these molecules, containing a biologically active group, was investigated on important metabolic enzymes (carbonic anhydrase isoenzymes I and II (hCA I and II), achethylcholinesterase (AChE), and α‐glycosidase (α‐Gly) enzymes).