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Supramolecular complexes of Ni (II) and Co (II) 4‐aminobenzoate with 3‐cyanopyridine: Synthesis, spectroscopic characterization, crystal structure, and enzyme inhibitory properties
Author(s) -
Sertçelik Mustafa,
Öztürkkan Özbek Füreya Elif,
Taslimi Parham,
Necefoglu Hacali,
Hökelek Tuncer
Publication year - 2021
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.6182
Subject(s) - chemistry , carboxylate , isostructural , crystallography , supramolecular chemistry , crystal structure , molecule , stereochemistry , carbonic anhydrase i , carbonic anhydrase , enzyme , organic chemistry
Two new complexes, [M (AB) 2 (CP) 2 (H 2 O) 2 ] (where M = Ni and Co AB = 4‐aminobenzoate and CP = cyanopyridine), were synthesized and characterized using different techniques (elemental analysis, FT‐IR spectrophotometer, LC/MS, single‐crystal X‐ray diffraction, and TGA/DTA analysis). As a result of X‐ray structural analysis, it was determined that complexes are isostructural. In the crystalline structures, M II ions are bridged with their carboxylate oxygen and aminopyridine nitrogen atoms and their symmetry‐related counterparts to form a two‐dimensional polymeric structure. The M II ion is octa‐coordinated with two nitrogen atoms and two oxygen atoms of the AB and two atoms of the CP anions. In this study, the effect of these molecules, containing a biologically active group, was investigated on important metabolic enzymes (carbonic anhydrase isoenzymes I and II (hCA I and II), achethylcholinesterase (AChE), and α‐glycosidase (α‐Gly) enzymes).