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Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di( N ‐ p ‐toluenesulfonyl) aminoacetates and the crystal structure of (4‐CH 3 C 6 H 4 SO 2 NHCH 2 CO 2 ) 2 Bi(C 6 H 4 Cl‐4) 3
Author(s) -
Yu Lin,
Ma YongQiang,
Wang GuoCang,
Song HaiBin,
Wang HongGeng,
Li JinShan,
Cui JingRong,
Wang RuiQing
Publication year - 2004
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.609
Subject(s) - chemistry , cytotoxicity , trigonal bipyramidal molecular geometry , stereochemistry , crystal structure , bismuth , crystallography , organic chemistry , in vitro , biochemistry
A series of triarylbismuth(V) di( N ‐ p ‐toluenesulfonyl)aminoacetates with the formula (4‐CH 3 C 6 H 4 SO 2 NHCH 2 CO 2 ) 2 BiAr 3 (ArC 6 H 5 , 4‐CH 3 C 6 H 4 , 4‐ClC 6 H 4 , 4‐BrC 6 H 4 ) were synthesized and characterized by elemental analysis, IR, 1 H NMR and mass spectra. The crystal structure of (4‐CH 3 C 6 H 4 SO 2 NHCH 2 CO 2 ) 2 Bi(C 6 H 4 Cl‐4) 3 was determined and shows the bismuth to exist in a distorted trigonal bipyramidal geometry. Four human neoplastic cell lines (HL‐60, PC‐3MIE8, BGC‐823 and MDA‐MB‐435) were used to screen these compounds. The results indicate that these compounds at 10 μ M show cytotoxicity. Copyright © 2004 John Wiley & Sons, Ltd.