Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di( N ‐ p ‐toluenesulfonyl) aminoacetates and the crystal structure of (4‐CH 3 C 6 H 4 SO 2 NHCH 2 CO 2 ) 2 Bi(C 6 H 4 Cl‐4) 3 | Zendy

Yu Lin | Zendy; Ma YongQiang | Zendy; Wang GuoCang | Zendy; Song HaiBin | Zendy; Wang HongGeng | Zendy; Li JinShan | Zendy; Cui JingRong | Zendy; Wang RuiQing | Zendy

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Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di( N ‐ p ‐toluenesulfonyl) aminoacetates and the crystal structure of (4‐CH 3 C 6 H 4 SO 2 NHCH 2 CO 2 ) 2 Bi(C 6 H 4 Cl‐4) 3

Author(s) -

Yu Lin,

Ma YongQiang,

Wang GuoCang,

Song HaiBin,

Wang HongGeng,

Li JinShan,

Cui JingRong,

Wang RuiQing

Publication year - 2004

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.609

Subject(s) - chemistry , cytotoxicity , trigonal bipyramidal molecular geometry , stereochemistry , crystal structure , bismuth , crystallography , organic chemistry , in vitro , biochemistry

A series of triarylbismuth(V) di( N ‐ p ‐toluenesulfonyl)aminoacetates with the formula (4‐CH 3 C 6 H 4 SO 2 NHCH 2 CO 2 ) 2 BiAr 3 (ArC 6 H 5 , 4‐CH 3 C 6 H 4 , 4‐ClC 6 H 4 , 4‐BrC 6 H 4 ) were synthesized and characterized by elemental analysis, IR, 1 H NMR and mass spectra. The crystal structure of (4‐CH 3 C 6 H 4 SO 2 NHCH 2 CO 2 ) 2 Bi(C 6 H 4 Cl‐4) 3 was determined and shows the bismuth to exist in a distorted trigonal bipyramidal geometry. Four human neoplastic cell lines (HL‐60, PC‐3MIE8, BGC‐823 and MDA‐MB‐435) were used to screen these compounds. The results indicate that these compounds at 10 μ M show cytotoxicity. Copyright © 2004 John Wiley & Sons, Ltd.

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