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A hexanuclear Nd (III) complex derived from a Schiff base with significant antitumor and antifungal activity
Author(s) -
Hua Lijuan,
Li Wenge,
Chen Yan,
Liang Kai,
Cai He,
Wang Jing,
Wang Siyu,
Yin Tianyue,
Liang Lili
Publication year - 2021
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.6081
Subject(s) - chemistry , schiff base , bromide , antifungal , stereochemistry , monomer , intramolecular force , hydrogen bond , ligand (biochemistry) , medicinal chemistry , molecule , biochemistry , organic chemistry , microbiology and biotechnology , receptor , polymer , biology
A hexanuclear Nd (III) complex {[Nd 6 (HL) 2 L 2 X 2 (NO 3 ) 8 (EtOH) 6 ]·(EtOH)(H 2 O) 3 } (H 2 L = 2,3‐dihydroxybenzaldehyde‐4‐aminoantipyrine; H 2 X = 2,3‐dihydroxy benzaldehyde) has been designed, synthesized, and evaluated for antitumor and antifungal activity. Single‐crystal X‐ray diffraction analysis indicates Nd (III) complex has a trinuclear cluster structure, which further forms a hexanuclear monomer through two bridging ligands L 2− . There are π–π interactions and a lot of intramolecular hydrogen bonds between monomers. Antitumor activity of Nd (III) complex against human hepatocellular carcinoma SMMC‐7721 cells has been studied by 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyltetrazolium bromide (MTT) assay and morphology observation. The IC 50 value of Nd (III) complex ranges from 4.02 to 4.85 μM, much smaller than that of clinical drug (gemcitabin) and free ligand (H 2 L), which is consistent with its high inhibition rate of 90%. Inhibitory zone of 26 mm reveals the significant antifungal activity of Nd (III) complex against Candida albicans .