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Synthesis, characterization and α ‐amylase and α ‐glucosidase inhibition studies of novel vanadyl chalcone complexes
Author(s) -
Kaur Mandeep,
Kaushal Raj
Publication year - 2021
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.6042
Subject(s) - chemistry , chalcone , antioxidant , electrospray ionization , stereochemistry , enzyme , nuclear chemistry , mass spectrometry , organic chemistry , chromatography
A series of chalcone ligands and their corresponding vanadyl complexes of composition [VO (L I–IV ) 2 (H 2 O) 2 ]SO 4 (where L I = 1,3‐Diphenylprop‐2‐en‐1‐one, L II = 3‐(2‐Hydroxy‐phenyl)‐1‐phenyl‐propenone, L III = 3‐(3‐Nitro‐phenyl)‐1‐phenyl‐propenone, L IV = 3‐(4‐Methoxy‐phenyl)‐1‐phenyl‐propenone) have been synthesized and characterized using various spectroscopic (Fourier‐transform infrared, electrospray ionization mass, nuclear magnetic resonance, electron paramagnetic resonance, thermogravimetric analysis, vibrating sample magnetometer) and physico‐analytic techniques. Antidiabetic activities of synthesized complexes along with chalcones were evaluated by performing in vitro and in silico α ‐amylase and α ‐glucosidase inhibition studies. The obtained results displayed moderate to significant inhibition activity against both the enzymes by vanadyl chalcone complexes. The most potent complexes were further investigated for the enzyme kinetic studies and displayed the mixed inhibition for both the enzymes. Further, antioxidant activity of vanadyl chalcone complexes was evaluated for their efficiency to release oxidative stress using 2,2‐diphenyl‐1‐picryl‐hydrazyl‐hydrate assay, and two complexes (Complexes 2 and 4 ) have demonstrated remarkable antioxidant activity. All the complexes were found to possess promising antidiabetic and antioxidant potential.