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New metal complexes of sulfonamide: Synthesis, characterization, in‐vitro anticancer, anticholinesterase, antioxidant, and antibacterial studies
Author(s) -
Danish Muhammad,
Raza Muhammad Asam,
Khalid Hirra,
Iftikhar Umara,
Arshad Muhammad Nadeem
Publication year - 2021
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.6033
Subject(s) - sulfonamide , chemistry , nuclear chemistry , antioxidant , antibacterial activity , metal , combinatorial chemistry , organic chemistry , bacteria , genetics , biology
In this research work a sulfonamide from tranexamic acid has been synthesized followed by its metal complexation. p ‐Bromo benzene sulfonyl chloride was used to synthesize sulfonamide using eco‐friendly atmosphere. The sulfonamide prepared from tranexamic acid has been utilized for the preparation of metal complexes with various metals like Ni, Cu, Co, Mn, Pb, Cd, Cr, Fe, Sn, and Sr. All synthesized compounds were characterized by applying different spectral techniques such as Fourier‐transform infrared (FTIR), mass spectrometry, and X‐ray diffraction (XRD) analysis. The biological activities such as radical scavenging activity, enzyme inhibition, antifungal, antibacterial, and anticancer were performed. It was concluded from the results that compounds showed moderate to good activity. Cu complex of sulfonamide showed the highest antioxidant potential (87.69 ± 1.8% with IC 50 137 ± 1.0 μg) while Cr complex depicted the highest activity against both enzymes; AChE (73.51 ± 1.7% with IC 50 165 ± 1.1 μg) and BChE (70.05 ± 1.3% with IC 50 152 ± 1.8 μg). Mn complex showed good results against six bacterial strains comparable with standard drug. Cr complex depicted highest anticancer activity against MCF7 and human corneal epithelial cell (HCEC) cell lines 45.73% and 25.40%, respectively. These results concluded that metal complexes of sulfonamide may be good induction in the future for medical purposes.