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Glycolic acid‐supported cobalt ferrite‐catalyzed one‐pot synthesis of pyrimido[4,5‐ b ]quinoline and indenopyrido[2,3‐ d ]pyrimidine derivatives
Author(s) -
Gholami Ahmad,
Mokhtary Masoud,
Nikpassand Mohammad
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.6007
Subject(s) - catalysis , thermogravimetric analysis , chemistry , cobalt , quinoline , glycolic acid , nuclear chemistry , fourier transform infrared spectroscopy , scanning electron microscope , transmission electron microscopy , infrared spectroscopy , ferrite (magnet) , inorganic chemistry , chemical engineering , organic chemistry , materials science , nanotechnology , composite material , lactic acid , biology , bacteria , engineering , genetics
Herein, one‐pot synthesis of pyrimido[4,5‐ b ]quinoline and indenopyrido[2,3‐ d ]pyrimidine derivatives was developed by the three‐component reaction of aldehydes, 6‐amino‐1,3‐dimethyluracil, and 1,3‐dicarbonyl compounds in the presence of glycolic acid‐supported cobalt ferrite CoFe 2 O 4 @SiO 2 @Si (CH 2 ) 3 NHCOOCH 2 COOH as a novel magnetic catalyst in ethanol at reflux conditions. Glycolic acid‐supported cobalt ferrite was characterized via Fourier transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy‐dispersive X‐ray spectroscopy (EDX), and vibrating sample magnetometer (VSM). Moreover, the catalyst was easily recovered with magnetic separation and recycled at least for five times without significant loss of its catalytic activity. The products were formed in excellent yields over appropriate reaction times under environmentally friendly conditions. The high efficiency and easy isolation of catalyst from products with an external permanent magnet are some of the remarkable advantages of this method.