Premium
The synthesis of N ‐containing heterocyclic compounds catalyzed by copper/ L ‐proline
Author(s) -
Wu Fengtian
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5975
Subject(s) - chemistry , proline , catalysis , ligand (biochemistry) , copper , combinatorial chemistry , tandem , cascade reaction , stereochemistry , organic chemistry , amino acid , receptor , biochemistry , materials science , composite material
N ‐containing heterocyclic compounds are one of the most important motifs prevalent in various bioactive natural products and pharmaceuticals. Given the significance of N ‐containing heterocyclic compounds, various synthetic strategies have been developed. Copper/ligand (abbreviated as [CuL])‐catalyzed cascade reaction is a powerful and efficient tool for the construction of N ‐containing heterocyclic compounds. L ‐proline is one universal ligand and has been utilized in the copper‐catalyzed reactions. In this review, copper/ L ‐proline‐catalyzed tandem reaction to synthesize the five‐ and six‐membered compounds is emphatically introduced. By comparing the yields in the presence and absence of the ligand, the importance of L ‐proline is recorded. Moreover, the function of L ‐proline is expounded on the basis of the reaction mechanism from original article.