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New organoruthenium metallates containing ferrocenecarboxalidine thiosemicarbazones and their nucleic acid/albumin binding and in vitro cytotoxicity
Author(s) -
Sindhu Mathiyazhagan,
Kalaivani Palaniappan,
Prabhakaran Rathinasabapathi
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5944
Subject(s) - chemistry , bovine serum albumin , cytotoxicity , dna , nucleic acid , electron paramagnetic resonance , quenching (fluorescence) , fluorescence , in vitro , titration , stereochemistry , nuclear chemistry , biochemistry , nuclear magnetic resonance , inorganic chemistry , physics , quantum mechanics
A string of four new hetero binuclear Ru(III) complexes of ferrocenecarboxaldehyde‐4( N) ‐substituted thiosemicarbazones were synthesized and characterized by various spectral (infrared, ultraviolet–visible, Electron Paramagnetic Resonance (EPR) and High Resolution Mass Spectrometry (HR‐MS) techniques. The binding abilities of the ligands/complexes with nucleic acid (calf thymus DNA, CT‐DNA) and bovine serum albumin (BSA) were analyzed by absorption and emission titration methods. The complexes exhibited better DNA binding affinity than their parent ligands. The interaction with CT‐DNA was found to be intercalative and with BSA static quenching mechanism was observed. All the synthesized Ru(III) complexes were subjected to study their in vitro cytotoxicity against MCF‐7 (human breast cancer) and HT‐29 (human colon cancer) cell lines. Among the four complexes, complex 3 [RuCp (FF‐etsc)PPh 3 ]Cl exhibited the highest cytotoxicity in MCF‐7 cells and complex 4 [RuCp (FF‐ptsc)PPh 3 ]Cl was the most active on HT‐29 cells.