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Synthesis of pyrimidine derivatives via multicomponent reaction catalyzed by ferric chloride
Author(s) -
Xian Liang,
Ma CuiTing,
Ouyang YingGen,
Di JiaQi,
Zhang ZhanHui
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5921
Subject(s) - chemistry , ferric , catalysis , environmentally friendly , pyrimidine , chloride , organic chemistry , combinatorial chemistry , coupling reaction , stereochemistry , ecology , biology
An eco‐friendly and practical approach was developed for the synthesis of pyrimidine derivatives via a one‐pot, three‐component coupling reaction of commercially available aldehydes, alkynes, and indazole3/triazole catalyzed by ferric chloride with good to excellent yields. The advantages of this method include environmentally friendly catalyst, easily available materials, and ease of product isolation.

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