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Retracted: A new porous Co(II)‐coordination polymer for the chemical fixation of CO 2 and treatment effect against tuberculosis by reducing the pckA expression in Mycobacterium tuberculosis
Author(s) -
Yan LiPing,
Sun Qin,
Liu ZhiBin,
Wu Min,
Ge YanPing,
Zhang Qing
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5908
Subject(s) - chemistry , in vivo , catalysis , mycobacterium tuberculosis , coordination polymer , chemical stability , polymer , nuclear chemistry , tuberculosis , organic chemistry , medicine , microbiology and biotechnology , pathology , biology
Using the mixed‐ligand method, a novel coordination polymer containing Co(II) of [Co(ditb)(tdc)] n ·5 n H 2 O ( 1 ) was prepared by reacting rigid 2,5‐thiophenedicarboxylic acid with flexible 1,4‐di(1H‐1,2,4‐triazol‐1‐yl)butane using the slow evaporation method. Active samples of 1 ( 1a for short) showed good stability and the ability to capture CO 2 . It can be used as a potential heterogeneous catalyst for chemical immobilization of epoxide and CO 2 to form cyclic carbonates. In addition, catalyst 1a retained its original structure after four times of reuse. Its biological properties were assessed against Mycobacterium tuberculosis ( M.TB ) both in vivo and in vitro. First, the bactericidal ability of the compound against M.TB was measured by a sterilization curve. Then, the expression of pckA gene related to M.TB survival was detected using reverse transcription‐polymerase chain reaction. For the in vivo study, the colony‐forming unit determination was performed for evaluating the anti‐bacterial effect of the compound, and the enzyme‐linked immunosorbent assay was used for the inflammatory cytokine measurement in vivo. Through molecular docking simulations, all three types of polar atoms on the complex were confirmed to have chances of interacting with the protein.