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Synthesis, structural characterization and in vitro antitumour properties of triorganoantimony(V) disalicylates: Crystal and molecular structures of [5‐Y‐2‐(ho)‐C 6 H 3 COO] 2 SbMe 3 (YH, Me, MeO)
Author(s) -
Silvestru Cristian,
Haiduc Ionel,
Tiekink Edward R. T.,
de Vos Dick,
Biesemans Monique,
Willem Rudolph,
Gielen Marcel
Publication year - 1995
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590090715
Subject(s) - chemistry , trigonal bipyramidal molecular geometry , antimony , carboxylate , crystallography , stereochemistry , crystal structure , molecule , in vitro , oxygen atom , inorganic chemistry , organic chemistry , biochemistry
Triorganoantimony(V) salicylates, [5‐Y‐2‐(HO)‐C 6 H 3 COO] 2 SbR 3 (R=Me, Ph; Y=H, Me, MeO), were obtained by reacting R 3 SbCl 2 with the appropriate sodium salt. The compounds have been characterized by IR, MS, 1 H and 13 C NMR spectroscopy. The molecular structure of the three substituted trimethylantimony(V) disalicylates has been determined by X‐ray diffraction. The salicylate ligands are mono‐coordinated to antimony through an oxygen atom of each carboxylate, leading to a trigonal bipyramidal geometry, with the antimony‐methyl groups in equatorial positions and the oxygen atoms in axial positions. The trimethylantimony compounds tested in vitro against a series of human tumour cell lines were found to be inactive.