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Catalytic asymmetric synthesis of propranolol and metoprolol using a La–Li–BINOL complex
Author(s) -
Sasai Hiroaki,
Suzuki Takeyuki,
Itoh Noriie,
Shibasaki Masakatsu
Publication year - 1995
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590090508
Subject(s) - chemistry , metoprolol , propranolol , catalysis , enantioselective synthesis , chloride , medicinal chemistry , lanthanum , stereochemistry , combinatorial chemistry , organic chemistry , anesthesia , medicine
The La–Li–( R )‐BINOL complex prepared from either lanthanum(III) chloride [LaCl 3 · 7H 2 O] or [La(O‐i‐Pr) 3 ] has made possible effective catalytic asymmetric syntheses of therapeutically important ß‐blockers such as propranolol and metoprolol. The possible stereochemical course of asymmetric nitroaldol reactions has been also clarified.