Synthesis and characterization of 7‐(CH 3 ) 3 N‐4‐ {2,4‐(NO 2 ) 2 C 6 H 3 S}‐ nido ‐7‐CB 10 H 11  and its Biodistribution in C 57 B 16  Mice Bearing B 16  Melanoma | Zendy

Morris John H. | Zendy; Peters Gavin S. | Zendy; Koldaeva Elena | Zendy; Spryshkova Raisa | Zendy; Borisov Gergy | Zendy

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Synthesis and characterization of 7‐(CH 3 ) 3 N‐4‐ {2,4‐(NO 2 ) 2 C 6 H 3 S}‐ nido ‐7‐CB 10 H 11 and its Biodistribution in C 57 B 16 Mice Bearing B 16 Melanoma

Author(s) -

Morris John H.,

Peters Gavin S.,

Koldaeva Elena,

Spryshkova Raisa,

Borisov Gergy

Publication year - 1995

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.590090405

Subject(s) - chemistry , characterization (materials science) , biodistribution , radiochemistry , nuclear chemistry , stereochemistry , nanotechnology , biochemistry , in vitro , materials science

7‐(CH 3 ) 3 N‐4‐{2,4‐(NO 2 ) 2 C 6 H 3 S}‐nido‐7‐CB 10 H 11 has been synthesized through a Friedel‐Crafts substitution reaction on 7‐(CH 3 )3N‐ nido ‐7‐ CB 10 H 12 . A biodistribution study in mice with implanted B16 melanoma indicates that the compound locates in neoplastic tissue at concentrations which suggest that its use in 10 B neutron capture therapy may be feasible.

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