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Synthesis and characterization of 7‐(CH 3 ) 3 N‐4‐ {2,4‐(NO 2 ) 2 C 6 H 3 S}‐ nido ‐7‐CB 10 H 11 and its Biodistribution in C 57 B 16 Mice Bearing B 16 Melanoma
Author(s) -
Morris John H.,
Peters Gavin S.,
Koldaeva Elena,
Spryshkova Raisa,
Borisov Gergy
Publication year - 1995
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.590090405
Subject(s) - chemistry , characterization (materials science) , biodistribution , radiochemistry , nuclear chemistry , stereochemistry , nanotechnology , biochemistry , in vitro , materials science
7‐(CH 3 ) 3 N‐4‐{2,4‐(NO 2 ) 2 C 6 H 3 S}‐nido‐7‐CB 10 H 11 has been synthesized through a Friedel‐Crafts substitution reaction on 7‐(CH 3 )3N‐ nido ‐7‐ CB 10 H 12 . A biodistribution study in mice with implanted B16 melanoma indicates that the compound locates in neoplastic tissue at concentrations which suggest that its use in 10 B neutron capture therapy may be feasible.